Science without religion is lame, religion without science is blind.

Physical concepts are free creations of the human mind, and are not, however it may seem, uniquely determined by the external world. In our endeavor to understand reality we are somewhat like a man trying to understand the mechanism of a closed watch. He sees the face and the moving hands, even hears its ticking, but he has no way of opening the case. If he is ingenious he may form some picture of a mechanism which could be responsible for all the things he observes, but he may never be quite sure his picture is the only one which could explain his observations. He will never be able to compare his picture with the real mechanism and he cannot even imagine the possibility or the meaning of such a comparison.

If we knew what we were doing, it wouldn't be called research, would it?

The whole of science is nothing more than a refinement of everyday thinking.

A great swindle of our time is the assumption that science has made religion obsolete. All science has damaged is the story of Adam and Eve and the story of Jonah and the Whale. Everything else holds up pretty well, particularly lessons about fairness and gentleness. People who find those lessons irrelevant in the twentieth century are simply using science as an excuse for greed and harshness. Science has nothing to do with it, friends.

No amount of experimentation can ever prove me right; a single experiment can prove me wrong.

One of the strongest motives that lead men to art and science is escape from everyday life with its painful crudity and hopeless dreariness, from the fetters of one's own ever-shifting desires. A finely tempered nature longs to escape from the personal life into the world of objective perception and thought.

Science never cheered up anyone. The truth about the human situation is just too awful.

Try and penetrate with our limited means the secrets of nature and you will find that, behind all the discernible concatenations, there remains something subtle, intangible and inexplicable. Veneration for this force beyond anything that we can comprehend is my religion. To that extent I am, in point of fact, religious. Response to atheist, Alfred Kerr (Winter 1927) who after deriding ideas of God and religion at a dinner party in the home of the publisher Samuel Fischer, had queried him "I hear that you are suppose to be deeply religious."

Even though the realms of religion and science in themselves are clearly marked off from each other, nevertheless there exist between the two strong reciprocal relationships and dependencies.

Science develops best when its concepts and conclusions are integrated into the broader human culture and its concerns for ultimate meaning and value. Scientists cannot, therefore, hold themselves entirely aloof from the sorts of issues dealt with by philosophers and theologians. By devoting to these issues something of the energy and care they give to their research in science, they can help others realize more fully the human potentialities of their discoveries. They can also come to appreciate for themselves that these discoveries cannot be a genuine substitute for knowledge of the truly ultimate. Science can purify religion from error and superstition; religion can purify science from idolatry and false absolutes. Each can draw the other into a wider world, a world in which both can flourish. Letter to the Reverend George V. Coyne, S.J., Director of the Vatican Observatory (1988-06-01).